Marine-derived fungi are known to be a prolific source of biologically active natural products which are useful for drug discovery. Nitrobenzoyl sesquiterpenoids are rare in natural sources, with only four reported examples from marine-derived Aspergillus fungi. Now...
06 09, 2014
The mechanism of a five-membered-ring formation in polycyclic tetramate macrolactams (PTMs; see picture) was demonstrated in ikarugamycin biosynthesis. Exploration of the IkaC-catalyzed reductive cyclization reveals a manner of polycycle formation via a Michael addition-like r...
05 04, 2014
The β-carboline (βCs) alkaloids possessing a tricyclic pyrido[3, 4-b]indole ring system are widely distributed in nature; the heterocyclic skeleton endows the βCs with antiallergic, antiviral, anti-inflammatory, antibacterial, and antitumor activities, and enables interacti...
12 31, 2013
Coral reefs in Hainan Island are very important and are suffering the influences from climate change and anthropogenic activities. Recent studies demonstrated that both climate change and anthropogenic activities are detrimental to coral reefs in Hainan Island, which was b...
10 31, 2013Invited by Prof. Changsheng Zhang, director of Research & Planning Office, Prof. Shu-Ming Li from Philipps-Universit？t Marburg and Prof. Ya-Zhong Xiao from Anhui University visited our insititute for academic exchange on 5th Sep, 2013. More than eighty faculties and students ...
09 30, 2013
Sugar moieties in many medicinal natural products are often critical for the biological activity, specificity and pharmacological properties. Attachments of sugars to natural product scaffold are catalyzed by glycosyltransferases (GTs) with either inversion or retention of con...
08 30, 2013
