Toxin/antitoxin (TA) systems are widespread in bacteria and archaea, and play prominent roles in cell physiology including altruistic behavior such as phage inhibition, global gene regulation, and tolerance to antibiotics. The cellular targets of these toxins are quite diverse...
06 17, 2014
Marine-derived fungi are known to be a prolific source of biologically active natural products which are useful for drug discovery. Nitrobenzoyl sesquiterpenoids are rare in natural sources, with only four reported examples from marine-derived Aspergillus fungi. ...
06 09, 2014
The mechanism of a five-membered-ring formation in polycyclic tetramate macrolactams (PTMs; see picture) was demonstrated in ikarugamycin biosynthesis. Exploration of the IkaC-catalyzed reductive cyclization reveals a manner of polycycle formation via a Michael addition-like ...
05 04, 2014
The marine actinomycete-derived Caerulomycin A (CRM A) was currently under the development as an immunosuppressive agent. Structurally, CRM A bears a unique 2,2'-bipyridine core and an unusual oxime functionality, the biosynthesis of which is rarely found in microbial secondar...
12 31, 2013
Mangroves are ever-green plant communities distributed along the tropical and subtropical coasts of the world. Since their great ecological importance, socio-economic significance, and obvious responses to global climate change, mangroves have become worldwide research focus.
07 31, 2013
